Selection and testing of new vaccine targets with invertebrate host antigens for the control of Canine Visceral Leishmaniasis on a platform of preclinical and clinical vaccine trials
Evaluation of the role of CD80 and CD86 molecules expressed by monocytes in the activation of CD4 + T lymphocytes and in targeting a pro-inflammatory and immunomodulatory profile in different forms of Chagas disease
Evaluation of the expression of matrix metalloproteinases and their inhibitors in individuals with different stages of non-alcoholic fatty liver disease in the search for prognostic biomarkers of evolution
T lymphocyte DNA extracellular traps: Its possible importance in host-parasite interactions and in the pathogenesis of American Cutaneous Leishmaniasis
Analysis of new imunotherapeutic and vaccinal formulations composed by chimeras containing phlebotomineal antigen and of the Leish-Tec® vaccine for visceral leishmaniasis
Identification and selection of vaccine targets to control the transmission of the Dengue, Chikungunya and Zika virus, using antigens from the invertebrate host Aedes aegypti
Study of fatty acid receptors and glucose CD36, FFAR2 and GLUT-1 in innate immunity cells and the relationship of their genetic polymorphisms with childhood obesity and associated comorbidities
Metalloproteinases as caspase-1-independent pathway in the activation of IL-1beta: a study of potential biomarkers of the evolution of clinical forms in Chagas disease
Evaluation of the immunological and epigenetic profile of individuals with different stages of non-alcoholic fatty liver disease in search of biomarkers of prognosis of evolution
Characterization of the intestinal microbiota and the expression and methylation profile in CD4 + T cell differentiation genes in childhood and juvenile obesity
Development and preclinical evaluation of chemotherapy strategies based on Trypanosoma cruzi redox metabolism inhibitors in the treatment of Chagas Disease
Pre-clinical trial of a recombinant Leishmania infantum protein and its immunoprophylactic and immunotherapeutic potential against visceral leishmaniasis.
